Dating someone with congenital hypothyroidism
Since the carboxyl group is added to the third carbon of the glutamate sidechain, known as the gamma (𝛄) carbon, the process is known as 𝛄-carboxylation.
Once modified in this way, glutamate becomes 𝛄-carboxyglutamate and is abbreviated “Gla.” Thus, vitamin K-dependent proteins often have the term “Gla” in their names.
You can share it using the button in the upper right corner, or the buttons on the bottom strip.
You can even use the button in the upper right corner to generate an embed code to share it on your own site if you have one.
One of those mechanisms is to stimulate the phosphorylation of protein kinase A (PKA), but how it does this is also unclear: some studies show that it increases cyclic AMP (c AMP), a traditional PKA activator, while other studies show it activates PKA independently from c AMP.
In other words, we know that MK-4 regulates gene expression, but we have a lot to learn about ).
Vitamin K supports the carboxylation of matrix Gla protein (MGP), which controls the distribution of calcium in the body and thereby supports the mineralization of bones and teeth, prevents the pathological calcification of soft tissues such as the heart, blood vessels, and kidneys, and supports growth during early development by preventing the premature calcification of growth plates. It has short stature because of calcified growth plates, suffers from osteopenia and spontaneous fractures, and dies within two months due to the rupture of heavily calcified blood vessels.
Future studies should be larger, at least three years long, and compare different doses and forms of vitamin K in different contexts to improve our understanding of how to best take advantage of this vitamin for bone health.
For now, the principle is sufficiently compelling to consider it likely over time that optimizing vitamin K intake is likely to provide meaningful benefits to bone health., but it also has direct antibacterial effects.
This conversion is variable between and even within species, and variation in the ability of humans to make the conversion could have contributed to the conflicting findings with menadione-laced chewing gum.
While no studies have yet clearly shown dietary or supplemental vitamin K to improve dental health, this is most likely a result of the dental field largely ignoring any role for nutrition in the prevention of tooth decay beyond the role of carbohydrates in promoting bacterial acid production.
This latter finding hints at a possibly very large reduction in the risk of fracture, but a larger study with sufficient numbers of fractures for statistical tests would be needed to confirm it.